Myogenic Response Is Independent of Endothelium
نویسندگان
چکیده
The purpose of this study was to investigate if myogenic responses of isolated coronary arterioles were dependent on an intact, functional endothelium. Arterioles were located in situ by intracoronary perfusion with india ink-gelatin solution and then dissected and cannulated at both ends with glass micropipettes. Intraluminal pressure was initially set at 60 cm H20; then the pressure was altered in steps of 20 cm H20 over a range of 20-140 cm H20. Arterioles developed spontaneous tone and exhibited a significant myogenic response in physiological saline solution (36°-37° C). Arteriolar dilation and constriction were observed at lower (20-60
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